3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester
β-hydroxylsovalerylshikonin
CAS: 7415-78-3
Molecular Formula: C21H24O7
3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester - Names and Identifiers
3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester - Physico-chemical Properties
| Molecular Formula | C21H24O7 |
| Molar Mass | 388.41 |
| Density | 1.312±0.06 g/cm3(Predicted) |
| Melting Point | 90-92 °C |
| Boling Point | 616.9±55.0 °C(Predicted) |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Appearance | Powder |
| pKa | 7.08±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD04038036 |
3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester - Reference
| Reference Show more | 1. [IF=3.503] Tao Pan et al."β-Hydroxyisovalerylshikonin regulates macrophage polarization via the AMPK/Nrf2 pathway and ameliorates sepsis in mice."Pharm Biol. 2022;60(1):729-742 |
3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester - Reference Information
| biological activity | Beta-hydroxyisovalerylshikonin is a natural product, it is a potent inhibitor of PTK with an IC50 of 0.7 μm and 1 μm for EGFR and v-Src receptors, respectively. Beta-hydroxyisovalerylshikonin has inhibitory effect on a variety of tumor cell lines, and can efficiently induce the death of NCI-H522 and DMS114 cells. |
| Target | IC50: 0.7 μm (EGFR), 1 μm (v-Src) |
Last Update：2024-04-09 21:32:09
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Product Name: β-hydroxylsovalerylshikonin Visit Supplier Webpage Request for quotationCAS: 7415-78-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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